Insulin-like growth factor binding protein-3 links obesity and breast cancer progression
نویسندگان
چکیده
منابع مشابه
Insulin-like growth factor binding protein-3 links obesity and breast cancer progression
Obesity is associated epidemiologically with poor breast cancer prognosis, but the mechanisms remain unclear. Since IGF binding protein-3 (IGFBP-3) influences both breast cancer growth and adipocyte maturation, it may impact on how obesity promotes breast oncogenesis. This study investigated the role of endogenous IGFBP-3 on the development of obesity and subsequently on breast tumor growth. Wi...
متن کاملInsulin-like growth factor-binding protein-3 and breast cancer survival.
Insulin-like growth factors (IGFs) are potent mitogens involved in the regulation of cell proliferation and apoptosis. The action of IGFs is mediated through a specific cell membrane receptor (IGF-IR), and the interactions between IGFs and this receptor are regulated by IGF-binding proteins (IGFBPs). IGFBP-3 is one such protein which either suppresses or enhances the actions of IGFs. Findings f...
متن کاملInsulin-like growth factor-binding protein-3, breast cancer risk, and different serum assays.
To the Editors: We are concerned about the potential misleading interpretations in the recently published study by Rinaldi et al. (1). In 2004, we reported the results of a systematic review determining the relationships between circulating total insulin-like growth factor-I (IGF-I) and total IGF-binding protein-3 (IGFBP-3) concentrations and cancer risk at several sites, including premenopausa...
متن کاملVertex balding, plasma insulin-like growth factor 1, and insulin-like growth factor binding protein 3.
BACKGROUND A recent report suggested that men with vertex balding have higher levels of plasma insulin-like growth factor 1 (IGF-1). The association of its major carrier protein, insulin-like growth factor binding protein 3 (IGFBP-3), with male pattern hair loss has not been examined. OBJECTIVE We evaluated the relations of plasma concentrations of IGF-1 and IGFBP-3 with vertex balding in mid...
متن کاملTargeting Insulin-Like Growth Factor Binding Protein-3 Signaling in Triple-Negative Breast Cancer
Insulin-like growth factor binding protein-3 (IGFBP-3) is a key regulatory molecule of the IGF axis and can function in a tissue-specific way as both a tumor suppressor and promoter. Triple-negative breast cancer (TNBC) has high tumor expression of IGFBP-3 associated with markers of poor prognosis and, although accounting for 15-20% of all breast cancers, is responsible for disproportionate rat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Oncotarget
سال: 2016
ISSN: 1949-2553
DOI: 10.18632/oncotarget.10675